Docetaxel Induced Hand Foot Syndrome - A Case Series

Palmar–plantar erythrodysesthesia, also known as hand–foot syndrome (HFS), can occur with a variety of cytotoxic chemo drugs including fluoropyrimidines, cytarabine, liposomal doxorubicin and taxanes. It often presents as painful erythemas and desquamation of the skin involving the palms of the hands and the soles of the feet. Three cases are presented of patients who received multiagent chemotherapy regimens containing docetaxel that developed an atypical presentation of HFS on the dorsal aspect of the hands and feet. Dorsal HFS improved with supportive care or dose reduction.