Observational analysis showed reduced liver injury in ovariectomized rats with Pimpinella Thellungiana, indicating potential metabolic benefits.
Key Points
The administration of Pimpinella Thellungiana significantly reduced liver tissue damage in ovariectomized rats, improving their metabolic profile and body weight.
Key findings include modulating insulin resistance, increasing irisin and adiponectin, and decreasing insulin and leptin levels after treatment with Pimpinella Thellungiana.
The approach involved using bilateral ovariectomy to model liver injury, combined with serum biochemical analysis and LC-MS/MS for metabolite evaluation.
These results highlight the potential of Pimpinella Thellungiana in regulating metabolic pathways and mitigating estrogen deficiency-induced liver damage.