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August 14, 2025

Protective effect of pirfenidone against ovarian ischemia/reperfusion injury in rats via modulation of TLR4/p38 MAPK/IL-1β and HIF-1α/VEGF-A signaling pathways.

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Authors

AAAsmaa Mohamed Abdel‐AzizMHMarwa HassanDTDina Moustafa Thabit

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Overview

Experimental evidence shows pirfenidone mitigates inflammation and oxidative stress in ovarian I/R injury, suggesting potential therapeutic roles.

Key Points

  • PFN treatment reduced markers of inflammation and oxidative stress after ovarian ischemia/reperfusion injury.
  • Histological analysis showed that PFN improved ovarian tissue morphology following injury.
  • The study utilized female rats to assess the efficacy of PFN over a 3-day treatment period.
  • Findings indicate that PFN's antioxidant properties may support angiogenesis by enhancing VEGF-A levels in the ovary.

Cite This Study

Abdel‐Aziz et al. (2025) studied this question.

synapsesocial.com/papers/689fc6852abb084d53ed23d3https://doi.org/10.1093/jpp/rgaf066
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Repurposing rupatadine to attenuate ovarian ischemia reperfusion in rats through modulation of PAF/NF-κB/TNF-α/IL-1β; HIF-1α/VEGF/Caspase 3 signaling pathways2025
  2. 2(691) The Protective Effect of Pirfenidone on Ischemia/Reperfusion Injury in an Experimental Rat Testicular Torsion Model2026
  3. 3Can monomethyl fumarate and nifedipine reduce ischemia reperfusion injury in rat ovary, and what is the share of oxidative stress-sensitive transcription factors HIF-1α, NF-κB, and Nrf2?2026
  4. 4Paeoniflorin Alleviates Oxygen–Glucose Deprivation/Reoxygenation Injury by Mediating Crosstalk Between Neurons and Endothelial Cells Through the VEGF/PI3K-AKT/mTOR Pathway2026
  5. 5The molecular mechanism of the protective effect of tianeptine against ovarian ischemia-reperfusion injury2025 · 1 citations