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October 1, 2025Kocaeli Üniversitesi Sağlık Bilimleri DergisiOpen Access

Ovarian Ischemia-Reperfusion Injury and the Potential Role of Mangiferin: A Histopathological, Biochemical Investigation

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Authors

HAHayat AyazFAFırat Aşır

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Overview

This study reports improved follicle counts and AMH levels in rats with ovarian injury, suggesting mangiferin may mitigate ischemic damage.

Key Points

  • Mangiferin significantly improved ovarian tissue health after ischemia-reperfusion injury.
  • Histopathological analysis indicated less vascular congestion and inflammatory cell infiltration with mangiferin treatment.
  • AMH levels and follicle counts were preserved in the IR+ Mangiferin group compared to the IR group.
  • Ovarian ischemia-reperfusion was induced by clamping vasculature, followed by reperfusion.

Cite This Study

Ayaz et al. (2025) studied this question.

synapsesocial.com/papers/68dd9537fe798ba2fc49972ehttps://doi.org/10.30934/kusbed.1730683
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  5. 5Repurposing rupatadine to attenuate ovarian ischemia reperfusion in rats through modulation of PAF/NF-κB/TNF-α/IL-1β; HIF-1α/VEGF/Caspase 3 signaling pathways2025