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This study aims to evaluate the protective effects of olivetol against ovarian ischemia/reperfusion injury.

March 26, 2026Journal of Laboratory Animal Science and PracticesOpen Access

Olivetol Mitigates Ovarian Ischemia/Reperfusion-Induced Oxidative and Inflammatory Damage via Enhancement of Antioxidant Defense

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Experimental study evaluates olivetol's effects on ovarian I/R injury, suggesting a potential therapeutic candidate.

This study aims to evaluate the protective effects of olivetol against ovarian ischemia/reperfusion injury.
Divided rats into eight groups: Sham, Sham + Olivetol, Ischemia, Ischemia + Olivetol, I/R, and I/R + Olivetol.
Induced ischemia by clamping the ovarian pedicle for 3 hours, followed by reperfusion in relevant groups.
Administered olivetol orally at different doses before ischemia or reperfusion induction.
Analyzed superoxide dismutase, glutathione, myeloperoxidase, and malondialdehyde levels in ovarian tissues.
SOD activity and GSH levels decreased significantly in ischemia and I/R groups compared to Sham.
Olivetol administration restored antioxidant parameters in a dose-dependent manner.
MPO and MDA levels were elevated after ischemia and reperfusion but decreased significantly with olivetol treatment, especially at the 100 mg/kg dose (p<0.001).
High-dose olivetol showed no toxic effects in healthy rats.

Özkan et al. (2026) studied this question.

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