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This study aims to assess the protective effects of ranolazine against ovarian ischemia/reperfusion injury in a rat model.

Protective Effects of Ranolazine in a Rat Model of Ovarian Ischemia/Reperfusion Injury

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Randomized trial evaluates ranolazine's effects on ovarian injury, suggesting protective benefits during ischemia.

This study aims to assess the protective effects of ranolazine against ovarian ischemia/reperfusion injury in a rat model.
Twenty-four female Wistar albino rats were randomly assigned to four groups: healthy, sham, I/R, and ranolazine-treated I/R.
Ovarian ischemia was induced by 1 hour of torsion followed by 6 hours of reperfusion.
Ranolazine was administered at 50 mg/kg one hour before ischemia induction.
Ranolazine treatment significantly reduced oxidative stress markers and inflammatory cytokines (p < 0.001).
Histopathological examination showed decreased follicular degeneration and improved COX-1 immunoreactivity in the ranolazine group.
Ranolazine also inhibited COX-2, IL-1β, and IL-6 expressions, indicating anti-inflammatory effects.

Admış et al. (2026) studied this question.

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