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September 10, 2025Scientific ReportsOpen Access

The molecular mechanism of the protective effect of tianeptine against ovarian ischemia-reperfusion injury

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Authors

BKBetul KalkanBYBülent YavuzerAAA. R. Aliyev

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Overview

Experimental analysis reveals tianeptine reduces oxidative stress and cytokines in ovarian ischemia-reperfusion injury, suggesting potential therapeutic benefits.

Key Points

  • Tianeptine significantly suppressed oxidative stress related to ovarian ischemia-reperfusion injury, alleviating damage.
  • Increased levels of malondialdehyde were observed in ovarian tissue due to ischemia-reperfusion, reflecting oxidative stress.
  • Assessment used histopathological and immunohistochemical methods to evaluate the effects of tianeptine in female rats.
  • The findings support tianeptine's potential role in protecting ovarian function from ischemic injury, warranting further investigation.

Cite This Study

Kalkan et al. (2025) studied this question.

synapsesocial.com/papers/68c1a78154b1d3bfb60e1105https://doi.org/10.1038/s41598-025-13875-7
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Also Consider

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  1. 1Protective Effects of Ranolazine in a Rat Model of Ovarian Ischemia/Reperfusion Injury2026
  2. 2OLIVETOL MITIGATES OVARIAN ISCHEMIA/REPERFUSION-INDUCED OXIDATIVE AND INFLAMMATORY DAMAGE VIA ENHANCEMENT OF ANTIOXIDANT DEFENSE2026
  3. 3The role of trimetazidine in ischemia/reperfusion damage treatment in an ovary torsion model experimentally induced in rats2022 · 2 citations
  4. 4Protective effect of pirfenidone against ovarian ischemia/reperfusion injury in rats via modulation of TLR4/p38 MAPK/IL-1β and HIF-1α/VEGF-A signaling pathways.2025
  5. 5Therapeutic Potential of Cepharanthine in Ovarian Ischemia-Reperfusion Injury: Insights from a Rat Ovarian Torsion-Detorsion Model2025