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February 16, 2022Journal of Obstetrics and Gynaecology

The role of trimetazidine in ischemia/reperfusion damage treatment in an ovary torsion model experimentally induced in rats

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Authors

ADAylin Önder DiricanMDMelike DoğanayHİHasan Ali İnal

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Overview

Randomized animal study demonstrates trimetazidine reduces histopathological damage from ovarian ischemia/reperfusion in rats, highlighting its potential protective role in adnexal torsion.

Key Points

  • To evaluate the histopathological and biochemical effects of trimetazidine in reducing tissue injury in an experimental rat model of ovarian ischemia/reperfusion.
  • Randomized 35 female Wistar albino rats into five equal groups (n = 7 per group): sham laparotomy, 2-hour ischemia, 2-hour ischemia followed by 2-hour reperfusion, sham with trimetazidine, and ischemia/reperfusion with trimetazidine.
  • Administered oral trimetazidine at 10 mg/kg twice daily for three days to the assigned treatment arms prior to surgical procedures.
  • Trimetazidine significantly decreased vascular congestion, hemorrhage, and polymorphonuclear leukocyte infiltration in the treated ischemia/reperfusion group compared to untreated ischemia/reperfusion controls (p < 0.05).
  • Reductions in biochemical markers of oxidative stress, including malondialdehyde, total oxidant status, and oxidative stress index values, did not reach statistical significance (p > 0.05).

Cite This Study

Dirican et al. (2022) studied this question.

synapsesocial.com/papers/6a8057966394d40ba7cabebfhttps://doi.org/10.1080/01443615.2022.2035332
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