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September 28, 2024Journal of Cardiovascular Medicine and CardiologyOpen Access

Both doses of TMZ increased the recovery biomechanical performance compared to the control group (p < 0.001), despite a negative inotropic effect under normoxic conditions (p < 0.001).

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Why the study?

Trimetazidine is a cardioprotective drug with anti-ischemic and anti-hypoxic actions, but its impact on contractile and recovery properties of isolated papillary heart muscle under normoxic and hypoxic conditions required investigation.

Does trimetazidine improve the contractile and recovery properties of isolated rat papillary heart muscle under hypoxic conditions?

Population

Left ventricular papillary muscles harvested from 40 Wistar rats

Comparison

Varying concentrations of TMZ (0 M, 5 x 10-6 M, and 5 x 10-5 M)

Design

Ex vivo experimental animal study

Authors

TEToygar Emre

Discussion

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Overview

Should not change TMZ practice; leaves open whether hypoxic contractile protection translates beyond isolated rat muscle.

Structured PICO

Does trimetazidine improve the contractile and recovery properties of isolated rat papillary heart muscle under hypoxic conditions?

P
Population
Left ventricular papillary muscles harvested from 40 Wistar rats
I
Intervention
Trimetazidine (TMZ) at concentrations of 5 x 10^-6 M and 5 x 10^-5 M
C
Comparator
Control group (0 M TMZ)
O
Outcome
Contractile and relaxation responses (biomechanical performance) under normoxic, hypoxic, and recovery conditionssurrogate

Trimetazidine at near-therapeutic doses improves postischemic recovery of contraction forces in isolated rat papillary muscles despite a negative inotropic effect under normoxic conditions.

Cite This Study

Toygar Emre (2024) studied this question.

synapsesocial.com/papers/6a80eb7a080e7f4ac74d5853https://doi.org/10.17352/2455-2976.000208
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Protective effects of trimetazidine on hypoxic cardiac myocytes from the rat1997 · 25 citations
  2. 2Effects of Trimetazidine on Ischemic Contracture in Isolated Perfused Rat Hearts1994 · 71 citations
  3. 3Pre-treatment with trimetazidine increases sarcolemmal mechanical resistance in reoxygenated myocytes1996 · 22 citations
  4. 4Trimetazidine Attenuates Exhaustive Exercise-Induced Myocardial Injury in Rats via Regulation of the Nrf2/NF-κB Signaling Pathway2019 · 53 citations
  5. 5Trimetazidine in the Prevention of Tissue Ischemic Conditions2018 · 29 citations