Why the study?
Does trimetazidine improve sarcolemmal resistance to reoxygenation-induced mechanical stress in isolated adult rat myocytes?
Population
Isolated adult rat myocytes submitted to 60 min of metabolic inhibition and 5 min of hypo-osmotic…
Comparison
Trimetazidine 100 mumol/l added to both… vs Control group undergoing metabolic inhibition…
Design
Preclinical
Follow-up
60 min of metabolic inhibition and 5 min of hypo-osmotic…
Authors
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May support cytoprotective effects of trimetazidine in myocytes; leaves open translation to clinical cardioprotection.
Does trimetazidine improve sarcolemmal resistance to reoxygenation-induced mechanical stress in isolated adult rat myocytes?
Preincubation with trimetazidine improves sarcolemmal resistance to reoxygenation-induced mechanical stress in isolated rat cardiomyocytes, potentially explaining its beneficial effect on infarct size.
Ruiz-Meana et al. (1996) studied this question.
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