Why the study?
Does trimetazidine protect cultured rat ventricular myocytes against functional alterations induced by substrate-free hypoxia?
Population
Cultured rat ventricular myocytes using a substrate-free hypoxia model of ischemia
Comparison
Trimetazidine (1-5.10 M final concentration) in… vs Untreated cells
Design
Preclinical
Follow-up
150 min normoxia or 150 min hypoxia followed by 90 min…
Authors
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May protect hypoxic myocytes in vitro; hypothesis-generating, should not yet change clinical practice.
Does trimetazidine protect cultured rat ventricular myocytes against functional alterations induced by substrate-free hypoxia?
Trimetazidine protects isolated rat cardiac myocytes against functional alterations induced by substrate-free hypoxia, potentially through ion channel blocking effects.
Fantini et al. (1997) studied this question.
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