Population
Rat isolated ventricular myocytes
Comparison
Trimetazidine applied for 2-3 hours or 5 hours… vs Control (absence of trimetazidine)
Design
Preclinical
Authors
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May modulate myocyte pH handling in rats; leaves open in vivo or clinical relevance.
Trimetazidine slows intracellular pH recovery following an acid load in rat ventricular myocytes, primarily by increasing intrinsic buffering power.
Lagadic‐Gossmann et al. (1996) studied this question.
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