Why the study?
Exhausted exercise can cause myocardial damage, but few studies have examined the effects of trimetazidine on myocardial injury induced by exhausted exercise.
Does trimetazidine attenuate exhaustive exercise-induced myocardial injury in a rat model?
Population
Rat model of exhaustive exercise induced by prolonged swimming
Comparison
Trimetazidine before exhaustive exercise vs control
Design
Animal experimental study
Authors
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Trimetazidine may protect rat myocardium from exhaustive exercise injury; hypothesis-generating, requires human trials before any clinical consideration.
Does trimetazidine attenuate exhaustive exercise-induced myocardial injury in a rat model?
Trimetazidine provides cardioprotection against exhaustive exercise-induced myocardial injury in rats via the Nrf2/NF-κB signaling pathway.
Zhang et al. (2019) studied this question.
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