Why the study?
Does trimetazidine improve left ventricular function or alter gene expression in rats with established infarct-induced heart failure?
Population
Rats with established infarct-induced heart failure
Comparison
Trimetazidine for 12 weeks vs Untreated rats
Design
Preclinical
Follow-up
12 weeks
Authors
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Trimetazidine lowers ANP mRNA without LV benefit in rat infarct HF; hypothesis-generating and should not guide clinical use.
Does trimetazidine improve left ventricular function or alter gene expression in rats with established infarct-induced heart failure?
Trimetazidine reduces atrial natriuretic peptide mRNA levels without improving left ventricular function in a rat model of established infarct-induced heart failure.
Morgan et al. (2006) studied this question.
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