Why the study?
Does trimetazidine improve cardiac function and clinical outcomes in patients with chronic heart failure?
Population
994 patients with chronic heart failure (CHF) pooled from 19 RCTs
Comparison
Trimetazidine (TMZ) vs Placebo
Design
Meta-analysis
Authors
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Supports adjunctive trimetazidine in chronic HF to improve LVEF and cut cardiac hospitalizations; confirms pooled RCT evidence without mortality benefit.
Does trimetazidine improve cardiac function and clinical outcomes in patients with chronic heart failure?
Trimetazidine therapy in chronic heart failure improves cardiac function, symptoms, and reduces cardiac hospitalizations, though it does not significantly affect all-cause mortality.
Zhou et al. (2014) studied this question.
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