Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Naunyn-Schmiedeberg s Archives of PharmacologyOpen Access

Repurposing rupatadine to attenuate ovarian ischemia reperfusion in rats through modulation of PAF/NF-κB/TNF-α/IL-1β; HIF-1α/VEGF/Caspase 3 signaling pathways

View Full Paper
Ask AI
Bookmark
Share

Authors

HKHanaa Mohamed KhalafSASara M. AhmedAAAlyaa Abdelfattah Abdelmonaem

Discussion

Loading...

Member takes

Overview

Observational study reveals rupatadine mitigates oxidative stress and inflammation in ovarian ischemia reperfusion, suggesting its therapeutic potential.

Key Points

  • Rupatadine significantly reversed ovarian damage caused by ischemia reperfusion injury.
  • Serum levels of anti-mullerian hormone dropped significantly due to injury, while oxidative markers rose.
  • The study utilized adult Wistar albino female rats to evaluate the effects of rupatadine on ovarian function.
  • These findings highlight the potential of rupatadine as a protective agent in ischemic conditions.

Cite This Study

Khalaf et al. (2025) studied this question.

synapsesocial.com/papers/68c192659b7b07f3a06175eehttps://doi.org/10.1007/s00210-025-04567-0
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Protective effect of pirfenidone against ovarian ischemia/reperfusion injury in rats via modulation of TLR4/p38 MAPK/IL-1β and HIF-1α/VEGF-A signaling pathways.2025
  2. 2Can monomethyl fumarate and nifedipine reduce ischemia reperfusion injury in rat ovary, and what is the share of oxidative stress-sensitive transcription factors HIF-1α, NF-κB, and Nrf2?2026
  3. 3Targeting Aquaporin-5 by Phosphodiesterase 4 Inhibition Offers New Therapeutic Opportunities for Ovarian Ischemia Reperfusion Injury in Rats2024 · 3 citations
  4. 4Protective Effects of Ranolazine in a Rat Model of Ovarian Ischemia/Reperfusion Injury2026
  5. 5Leptin alleviated ovarian ischemia-reperfusion injury in rats via modulation of Sirt-1/Nrf2 and TLR4/NF-kB/caspase-3 signaling pathways2023 · 11 citations