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January 1, 2023Endocrine RegulationsOpen Access

Leptin alleviated ovarian ischemia-reperfusion injury in rats via modulation of Sirt-1/Nrf2 and TLR4/NF-kB/caspase-3 signaling pathways

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Why the study?

Ovarian torsion is a gynecological emergency, and this study aimed to explore the probable protective effect of leptin on rat ovaries against ischemia-reperfusion injury.

Does leptin alleviate ovarian ischemia-reperfusion injury in a rat model?

Population

Wistar albino rats

Comparison

Control vs ovarian IR vs ovarian IR with leptin (10 µg/kg or 100 µg/kg)

Design

Animal experimental study

Authors

HAHeba A. Abdel‐HamidAl Baha UniversityNMNehad MR. Abdel MaqsoudNTNisreen DM ToniMinia University

Discussion

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Implication

May warrant caution in human ovarian torsion; leaves open leptin's protective role pending clinical trials.

Structured PICO

Does leptin alleviate ovarian ischemia-reperfusion injury in a rat model?

P
Population
Wistar albino rats with ovarian ischemia-reperfusion (IR) injury
I
Intervention
Leptin (10 µg/kg or 100 µg/kg body weight)
C
Comparator
Ovarian IR group without leptin and healthy control group
O
Outcome
Serum levels of estradiol and anti-Mullerian hormone (AMH), oxidative stress and inflammatory markers, and expression of Sirt1, Nrf2, COX-2, NF-κB, TLR4, and caspase-3surrogate

Leptin dose-dependently reduces the severity of ovarian ischemia-reperfusion injury in rats by modulating Sirt-1/Nrf2 and TLR4/NF-kB/caspase-3 signaling pathways.

Limitations

  • Clinical studies are needed to evaluate these results in humans

Cite This Study

Abdel‐Hamid et al. (2023) studied this question.

synapsesocial.com/papers/6a70f2dc78a11c550e0afa47https://doi.org/10.2478/enr-2023-0004

Topics

Bremelanotide
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Leptin Impairs the Synergistic Stimulation by Transforming Growth Factor-β of Follicle-Stimulating Hormone-Dependent Aromatase Activity and Messenger Ribonucleic Acid Expression in Rat Ovarian Granulosa Cells11999 · 81 citations
  2. 2Acute Leptin Treatment Enhances Functional Recovery after Spinal Cord Injury2012 · 71 citations
  3. 3Synergistic effect of leptin and lipidized PrRP on metabolic pathways in ob/ob mice2019 · 16 citations
  4. 4Etanercept protects ovarian reserve against ischemia/reperfusion injury in a rat model2019 · 58 citations
  5. 5Circulating leptin and NF‐κB activation in peripheral blood mononuclear cells across the menstrual cycle2016 · 19 citations