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May 6, 2026

Can monomethyl fumarate and nifedipine reduce ischemia reperfusion injury in rat ovary, and what is the share of oxidative stress-sensitive transcription factors HIF-1α, NF-κB, and Nrf2?

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Authors

BKBegüm KurtZİZeynep Deniz Şahin İnanSDSevgi Durna Daştan

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Overview

Mixed treatment improved ovarian function and reduced oxidative stress in ischemia reperfusion injury, indicating transcription factors may play crucial roles.

Key Points

  • The study investigates the protective effects of monomethyl fumarate and nifedipine against ischemia reperfusion injury in rat ovaries.
  • Established a rat model of ovarian ischemia-reperfusion injury using 3 hours of ischemia followed by 24 hours of reperfusion.
  • Analyzed ovarian hormone secretion and oxidative stress via ELISA.
  • Evaluated histopathological damage and apoptosis with immunohistochemical staining and H&E.
  • Measured gene expression of HIF-1α, NF-κB, Nrf2, and related genes using RT-qPCR.
  • Combined treatment with MMF and NF restored serum AMH and E2 levels towards control values.
  • Reduced oxidative stress markers including TOS and MDA in treated rats.
  • Gene expression levels of pro-apoptotic markers like BAX improved under the influence of MMF and NF.

Cite This Study

Kurt et al. (2026) studied this question.

synapsesocial.com/papers/69fa98bd04f884e66b5328cbhttps://doi.org/10.22038/ijbms.2026.89192.19254
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Also Consider

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