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June 6, 2026The Journal of Sexual Medicine

(691) The Protective Effect of Pirfenidone on Ischemia/Reperfusion Injury in an Experimental Rat Testicular Torsion Model

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Authors

AAA T AlbayrakSAS AdaSTS Türk

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Overview

Randomized trial evaluates Pirfenidone’s protective effect against testicular injury in rats, implying potential therapeutic use.

Key Points

  • This study aims to evaluate the protective effects of Pirfenidone on ischemia/reperfusion injury in a rat model of testicular torsion.
  • 21 adult male Sprague-Dawley rats were randomized into four groups: Control, Sham, Torsion/Detorsion, and Torsion/Detorsion + Pirfenidone.
  • The T/D and PFD groups underwent 4 hours of ischemia followed by 24 hours of reperfusion, with Pirfenidone administered prior to reperfusion.
  • Biochemical analysis included measuring various tissue and serum markers, alongside histopathological examination.
  • IL-1β and TGF-β levels in the T+D group were significantly higher than in the control (p=0.001 and p<0.001).
  • Pirfenidone treatment significantly reduced IL-1β and TGF-β levels compared to T/D group (p=0.003 and p<0.001).
  • While several markers showed changes in the PFD group, the results did not reach statistical significance.

Cite This Study

Albayrak et al. (2026) studied this question.

synapsesocial.com/papers/6a23bbeb71a5da9775e7742ehttps://doi.org/10.1093/jsxmed/qdag118.601
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