September 11, 2025

Are the dermatological cut-off values of commercially available ELISAs for BP180-NC16A appropriate when applied for diagnosis of oral mucous membrane pemphigoid?. Results of a preliminary study.

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Authors

AGAndrea GabusiUniversity of Bologna FFFederica FilippiAzienda USL di Bologna CLCamilla LoiAzienda USL di Bologna

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Implication

This preliminary analysis identifies optimal cut-off levels for BP180-NC16A ELISA in oral mucous membrane pemphigoid, highlighting sensitivity and specificity issues.

Key Points

A cutoff of 11 U/mL for BP180-NC16A ELISA improved sensitivity to 70.97% when diagnosing oral mucous membrane pemphigoid.
The current ELISA cutoff of 20 U/mL showed high specificity (94%) but low sensitivity (41.94%) for oral mucous membrane pemphigoid.
Evaluations included 81 patients divided into OMMP and control groups, assessed via histological methods and immunofluorescence.
Customized cutoff values for OMMP should be developed to enhance clinical utility despite challenges of false positives.

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Gabusi et al. (2025) studied this question.

synapsesocial.com/papers/68c2a9c304ab598fffb89d18 https://doi.org/10.23736/s2724-6329.25.05004-1

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Implication

This preliminary analysis identifies optimal cut-off levels for BP180-NC16A ELISA in oral mucous membrane pemphigoid, highlighting sensitivity and specificity issues.

Are the dermatological cut-off values of commercially available ELISAs for BP180-NC16A appropriate when applied for diagnosis of oral mucous membrane pemphigoid?. Results of a preliminary study.

Discussion

Member takes

Implication

Key Points

Cite This Study

Are the dermatological cut-off values of commercially available ELISAs for BP180-NC16A appropriate when applied for diagnosis of oral mucous membrane pemphigoid?. Results of a preliminary study.

Discussion

Member takes

Implication

Key Points

Cite This Study

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