What question did this study set out to answer?

To review the prevalence of preclinical BP autoantibodies targeting BP180 and BP230 and discuss their clinical significance in predicting bullous pemphigoid onset.

August 8, 2022Frontiers in ImmunologyOpen Access

The significance of preclinical anti-BP180 autoantibodies

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Authors

YMYosuke Mai KIKentaro Izumi SMShoko Mai

Discussion

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Overview

Review uncovers the prevalence of preclinical anti-BP180 autoantibodies in high-risk populations, indicating their diagnostic value for predicting bullous pemphigoid.

Key Points

To review the prevalence of preclinical BP autoantibodies targeting BP180 and BP230 and discuss their clinical significance in predicting bullous pemphigoid onset.
Synthesized findings from epidemiological and observational literature evaluating preclinical BP autoantibody detection.
Examined antibody prevalence across vulnerable cohorts, including elderly populations and individuals with comorbid disorders predisposing them to bullous pemphigoid.
Preclinical autoantibodies against BP180 and BP230 can circulate prior to the clinical manifestation of tense blisters.
Autoantibodies are detectable in a low percentage of healthy individuals but occur with higher frequency in populations susceptible to bullous pemphigoid or comorbid disease.
Preclinical antibody presence represents a potential predictive risk factor for the subsequent clinical emergence of bullous pemphigoid.

Cite This Study

Mai et al. (2022) studied this question.

synapsesocial.com/papers/6a8bca7fe6afc07dcbf45a6d https://doi.org/10.3389/fimmu.2022.963401

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August 8, 2022Frontiers in ImmunologyOpen Access

The significance of preclinical anti-BP180 autoantibodies

View Full Paper

Ask AI

Bookmark

Authors

YMYosuke Mai KIKentaro Izumi SMShoko Mai

Discussion

Member takes

Overview

Review uncovers the prevalence of preclinical anti-BP180 autoantibodies in high-risk populations, indicating their diagnostic value for predicting bullous pemphigoid.

Key Points

To review the prevalence of preclinical BP autoantibodies targeting BP180 and BP230 and discuss their clinical significance in predicting bullous pemphigoid onset.
Synthesized findings from epidemiological and observational literature evaluating preclinical BP autoantibody detection.
Examined antibody prevalence across vulnerable cohorts, including elderly populations and individuals with comorbid disorders predisposing them to bullous pemphigoid.
Preclinical autoantibodies against BP180 and BP230 can circulate prior to the clinical manifestation of tense blisters.
Autoantibodies are detectable in a low percentage of healthy individuals but occur with higher frequency in populations susceptible to bullous pemphigoid or comorbid disease.
Preclinical antibody presence represents a potential predictive risk factor for the subsequent clinical emergence of bullous pemphigoid.

Cite This Study

Mai et al. (2022) studied this question.

synapsesocial.com/papers/6a8bca7fe6afc07dcbf45a6d https://doi.org/10.3389/fimmu.2022.963401

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