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November 12, 2025International Journal of DermatologyOpen Access

Sensitivity and Specificity of ELISA Tests Detecting BP180 and BP230 Antibodies in the Diagnosis of Bullous Pemphigoid: A Systematic Review and Meta‐Analysis

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Authors

MGMonika Grochowska-RakKKKatarzyna KuligAGArleta Grabowska

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Overview

Systematic review and meta-analysis confirm high diagnostic accuracy of BP180 ELISA in bullous pemphigoid, highlighting its clinical value.

Key Points

  • This research aims to assess the diagnostic performance of ELISA tests for BP180 and BP230 in bullous pemphigoid.
  • Conducted a systematic review and meta-analysis following PRISMA guidelines.
  • Searched databases including PubMed, Embase, and CENTRAL for relevant studies.
  • Evaluated 17 studies with 1768 bullous pemphigoid patients and 1382 controls.
  • BP180 ELISA showed pooled sensitivity of 82.0% and specificity of 94.1%.
  • BP230 ELISA had lower sensitivity at 58.6% but high specificity of 94.8%.
  • Risk of bias was found to be generally low.

Cite This Study

Grochowska-Rak et al. (2025) studied this question.

synapsesocial.com/papers/692523cec0ce034ddc3552b3https://doi.org/10.1111/ijd.70136
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Risk of Bias and Reporting Quality in <scp>BP180</scp> / <scp>BP230 ELISA</scp> Diagnostic Studies of Bullous Pemphigoid: A Meta‐Epidemiological Study2026
  2. 2Anti-BP230 IgE autoantibodies in bullous pemphigoid intraindividually correlate with disease activity2024 · 9 citations
  3. 3Chemiluminescence Immunoassay and Enzyme-Linked Immunosorbent Assay in the Diagnosis of Pemphigoid and Pemphigus: A Comparative Study2026
  4. 4Are the dermatological cut-off values of commercially available ELISAs for BP180-NC16A appropriate when applied for diagnosis of oral mucous membrane pemphigoid?. Results of a preliminary study.2025
  5. 5Diagnostic challenge: Juvenile bullous pemphigoid with a negative <scp>BP180 ELISA</scp>2024