Meta-epidemiological study assesses bias and reporting quality in BP180/BP230 ELISA diagnostic studies, highlighting implications for clinical accuracy.
Key Points
The aim is to evaluate if methodological flaws and incomplete reporting influence accuracy estimates of BP180 and BP230 ELISA tests for diagnosing bullous pemphigoid.
Meta-epidemiological methodological study of 18 published diagnostic accuracy studies from 2004 to 2025
Risk of bias assessed using QUADAS‐2, reporting quality evaluated with a STARD-based checklist
No new pooled meta-analysis was performed.
83% of studies (15/18) had high risk of bias in patient selection
Median sensitivity/specificity were 0.82/0.94 for BP180 and 0.58/0.98 for BP230
Sensitivity of BP180 was lower in low-risk studies (0.69) compared to high/unclear risk studies (0.84; p=0.09).
Cite This Study
Grochowska‐Rak et al. (2026) studied this question.