Cascade reactions utilize engineered transaminases to synthesize amino sugars, suggesting potential in high-value production.
This work reports cascade reactions using a pyranose 2-oxidase and transaminases for synthesizing the rare amino sugars mannosamine, glucosamine, and galactosamine. Transaminases were engineered to accept unnatural 2-keto-sugars, providing up to 68% galactosamine yield. The mechanisms of C2-amination by these transaminases were also investigated. These transaminase variants have potential applications in high-value amino sugar synthesis.
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Chuaboon et al. (2025) studied this question.
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