Experimental study demonstrates one-pot amination of benzylic alcohols using enzymatic cascades, suggesting sustainable routes for synthesizing pharmaceutical compounds like naftifine.
The amination of benzylic and cinnamic alcohols was achieved via a biocatalytic, one-pot oxidation–transamination cascade in aqueous medium at physiological conditions. Alcohol oxidation by galactose oxidase at the expense of O2 furnished the corresponding aldehydes, which were aminated using ω-transaminases in situ. The applicability of this method was demonstrated by a short synthesis of the antifungal agent naftifine.
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Fuchs et al. (2012) studied this question.
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