This research demonstrates Atf6 inhibition reduces the protective effects of Pasireotide, indicating potential implications for endothelial function and inflammation.
Activating transcription factor 6 (ATF6) is an unfolded protein response (UPR) sensor with a significant role in endothelial integrity and barrier function. This study investigates the effects of Ceapin-A7, which is an ATF6 suppressor, in mediating the protective effects of Pasireotide (PAS) in the endothelium. Ceapin-A7 suppressed PAS-induced Grp94 augmentation, cofilin deactivation and MLC2 dephosphorylation. Furthermore, ATF6 inhibition counteracted the anti-oxidative and anti-inflammatory effects of PAS in human and lung endothelial cells as evidenced by the increased ROS generation and pSTAT1, pSTAT3, pERK1/2, and pP38 suppression. Our study adds information on the protective actions of Pasireotide in endothelial cells and supports ongoing efforts to enrich our knowledge on the pathophysiology of sepsis and lung injury.
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Fakir et al. (2025) studied this question.
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