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September 14, 2025

Pilot-Optimizing Transfusion Therapy in Critically Ill Children With Anemia: A Pilot Multicenter Electronic Health Record-Enabled Randomized Controlled Trial on Red Blood Cell Transfusion in Critically Ill Children.

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Pilot RCT evaluates RBC transfusion strategies in anemic critically ill children, indicating potential for international trial feasibility.

The study shows successful recruitment and adherence rates exceeding 80% among critically ill children with anemia.
It achieved an electronic data extraction rate of 87.7% from electronic health records, indicating robust systems in place.
Participants demonstrated low pre-transfusion hemoglobin levels, though separation from predefined criteria was insufficient.
The findings imply the need for clearer transfusion Hb thresholds in future international trials.

Tucci et al. (2025) studied this question.

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Pilot RCT evaluates RBC transfusion strategies in anemic critically ill children, indicating potential for international trial feasibility.