This protocol demonstrates cascade cyclization using visible light to create acyl benzo[b]azepines, indicating a practical method for diverse derivatives.
A visible light-induced radical-cascade acylation/cyclization involving 1,7-dienes and acyl chlorides has been developed. This protocol presents a practical and environmentally benign method for the preparation of diverse acyl benzo[b]azepine derivatives in high yields. The gram-scale synthesis and late-stage modification show the applicability of the reaction. Further radical trapping experiments and luminescence quenching studies elucidate the reaction mechanism.
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Fang et al. (2025) studied this question.
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