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September 14, 2025

Humoral immunity to current variants of SARS-CoV-2 in exposed adults, September 2023 to September 2024.

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Authors

LJLara M. JeworowskiBMBarbara MühlemannFWFelix Walper

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Overview

Observational analysis reports updated humoral immunity to SARS-CoV-2 variants in vaccinated adults, indicating ongoing exposure helps adapt community immunity.

Key Points

  • Neutralizing antibody titers against SARS-CoV-2 variants increased over time, reflecting immune adaptation.
  • Increased immune responses were noted, with the highest fold increases against variants KP.3.1.1 and XEC.
  • The study followed 58 vaccinated adults over one year, analyzing their responses to multiple SARS-CoV-2 variants.
  • Despite increasing neutralization titers, overall group-level activity remained low, suggesting a need for vaccine updates.

Cite This Study

Jeworowski et al. (2025) studied this question.

synapsesocial.com/papers/68c6df6de03a6c7bdc170fdehttps://doi.org/10.1128/mbio.01618-25
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