September 16, 2025

Metabolic Tagging Reveals Surface-Associated Lipoproteins in Mycobacteria.

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Metabolic tagging shows active incorporation of fatty acids in mycobacteria, suggesting roles for lipoproteins in transport processes.

Incorporation of azido palmitic acid reveals active processes linked to the lipoprotein biosynthesis pathway, and suggests potential transport mechanisms.
A subset of lipid-modified proteins is associated with the cell surface of mycobacteria, specifically in Mycobacterium tuberculosis and M. smegmatis.
Characterization of metabolic incorporation methods may aid in the detection and enrichment of lipid-modified proteins across multiple bacterial species.
These findings provide insights into poorly understood pathways related to lipoprotein function in mycobacteria and other bacteria.

Parkin et al. (2025) studied this question.

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