Iron-catalyzed carboxylation generates isoniazid derivatives from pyridylphosphonium salts, indicating broad functional group tolerance.
Iron is the most abundant transition metal on earth and exhibits the lowest toxicity. However, the iron-catalyzed carboxylation reaction utilizing CO2 remains significantly underexplored. Here we report an efficient iron-catalyzed carboxylation of pyridylphosphonium salts with CO2, which enables the synthesis of a variety of high value-added isoniazid derivatives. This reaction demonstrates excellent tolerance for a wide range of functional groups and possesses high synthetic practicality. The primary catalytic cycle in this reaction may involve an Fe(0)-Fe(I)-Fe(II)-Fe(0) redox sequence.
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Tang et al. (2025) studied this question.
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