Experimental study demonstrates continuous flow palladium-catalyzed carbonylation using iron pentacarbonyl, indicating an accessible route to natural products and aryl halide derivatives.
This work discloses a continuous flow carbonylation reaction using iron pentacarbonyl as source of CO. The described transformation using this surrogate was designed for use in commonly accessible flow equipment. Optimized conditions were applied to a scalable synthesis of the natural compound isolated from perianal glandular pheromone secretion of the African civet cat. In addition, a flow Pd-catalyzed carbonylation of aryl halides is successfully reported.
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Lopatka et al. (2019) studied this question.
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