Abstract We report the formation of tetrazolidinones and thiatetrazolidines, i.e., heterocycles with four σ‐bonded nitrogen atoms in their structure, via the oxidative coupling of two hydrazines tethered by a carbonyl or a sulfonyl moiety. Different strategies for installing the tethers on the various bishydrazine precursors are first presented, and their cyclization is presented next. The influence of the protecting groups on the α and/or β nitrogen atoms, as well as the nature of the oxidant leading to the tetrazane core, is studied.
Bretones et al. (Tue,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: