Phytochemical analysis reveals three phenanthrene derivatives with cytotoxicity against prostate cancer, suggesting therapeutic potential.
Phytochemical analysis on the entire plant of Pinalia densa disclosed the existence of three new phenanthrene derivatives, named pinadensins A-C (1-3), in addition to ten known compounds (4-13). Structural elucidation of all new compounds was accomplished by several interpreting spectroscopic data such as CD, MS and NMR. Pinadensin A (1) and 9,9'-O-di-(E)-feruloyl-(-)-secoisolariciresinol (12) induced cytotoxic effects in human prostate cancer cell lines (PC-3 and DU145) as well as human normal keratinocyte HaCaT cells in relation to the dose; with an IC50 value of 30.97 ± 9.0 μM, liparisphenanthrene B (11) demonstrated significant cytotoxic action on PC-3, while having a less cytotoxic impact on HaCaT cells.
No takes yet. Share an insight, caveat, or question.
Ploithoom et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: