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September 12, 2025Open Access

Multi-Metric Genomic Profiling of SARS-CoV-2 Spike Mutations (2020 - 2025): Decoding Evolutionary and Lineage Specific Patterns

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Authors

TBTahir BhattiUniversity of Modern Sciences

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Implication

Data-driven analysis shows immune escape and transmissibility trends in SARS-CoV-2 lineages, suggesting proactive genomic surveillance.

Key Points

  • High-fitness mutation clusters in SARS-CoV-2 spike proteins enhance transmissibility and fusion stability.
  • Analysis of 7.4 million sequences revealed new variants such as KP.2, LB.1, and FL.1.5.1 with immune evasion traits.
  • A predictive model using transition probabilities accurately forecasted emerging lineages months in advance.
  • This innovative approach shifts genomic surveillance from reactive to proactive, aiding vaccine design and therapeutic updates.

Cite This Study

Tahir Bhatti (2025) studied this question.

synapsesocial.com/papers/68d44a3031b076d99fa531ebhttps://doi.org/10.20944/preprints202509.0925.v1
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