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September 12, 2025Engineering in Life SciencesOpen Access

A Novel Raman‐Chromatography Assembly for Automated Calibration and In‐Line Monitoring in Bioprocessing

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Authors

JHJakob Heyer‐MüllerRSRobin SchiemerMLMatthias Lopinski

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Overview

Novel assembly enhances real-time monitoring of buffer and protein concentrations in bioprocessing, suggesting improved accuracy.

Key Points

  • The novel raman-chromatography assembly enables real-time monitoring of protein and buffer concentrations.
  • Chemometric PLS models demonstrated strong alignment in calibration datasets, achieving R2 and Q2 metrics.
  • This approach automates the generation of representative data for calibration in bioprocessing applications.
  • Results highlight the potential for improved accuracy in in-line monitoring during the ultrafiltration process.

Cite This Study

Heyer‐Müller et al. (2025) studied this question.

synapsesocial.com/papers/68d44a3731b076d99fa5346ehttps://doi.org/10.1002/elsc.70044
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