Observational analysis shows low toxicity of heterocyclic aminocontaining compounds in breast cancer cell lines, suggesting potential as anticancer agents.
The cytotoxic activity of heterocyclic amino-containing derivatives of 1,4-naphthoquinone in vitro on various human breast cancer lines, namely: MDA-MB, MCF-7, SK-BR-3, BT-474 and non-cancerous cell lines (MCF-10A) was investigated. In silico prediction of toxicity of the test substances for rats was performed using modern software ProTox-II. It was established that all studied compounds belong to toxicity classes IV and VI and are of low toxicity. It was determined that heterocyclic amino-containing derivatives of 1,4-naphthoquinone can be used as potent anticancer agents with cytotoxic activity against MCF-7 and MDA-MB-231.
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Polish et al. (2025) studied this question.
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