This novel assay identifies impaired visual function in zebrafish, suggesting practical applications in neuroscience and drug discovery.
The optokinetic response (OKR) is a widely used measure of visual and neurological function in zebrafish (Danio rerio). In this study, we employed a simple and cost-effective OKR assay system for adult zebrafish utilizing a mobile phone and a stereomicroscope. The setup was validated by comparing control fish with those exposed to light-induced retinal degeneration (LIRD), demonstrating significantly impaired OKR responses. This custom-made setup offers valuable applications in visual neuroscience, disease modeling, and drug discovery.
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Gunaseelan et al. (2025) studied this question.
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