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September 12, 2025JAMA Network OpenOpen Access

Excess HIV Infections and Costs Associated With Reductions in HIV Prevention Services in the US

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Authors

PSPatrick S. SullivanKWKristin M. WallMJMárta Juhász

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Overview

Economic evaluation finds that reduced PrEP access could lead to thousands of new HIV infections, suggesting significant health care costs.

Key Points

  • Estimated decrease in PrEP coverage could lead to 8618 new HIV infections over the next decade, emphasizing the urgency of maintaining PrEP access.
  • Lifetime treatment costs for avoidable HIV infections could reach $3.6 billion, highlighting the economic impact of reduced PrEP coverage.
  • Using US population data, analysis shows a direct correlation between PrEP use reductions and increased HIV infection rates, demonstrating a need for policy support.
  • Modest policy-induced reductions in PrEP coverage could drastically increase health care costs and HIV transmission rates, underscoring potential public health implications.

Cite This Study

Sullivan et al. (2025) studied this question.

synapsesocial.com/papers/68d44a4031b076d99fa537ebhttps://doi.org/10.1001/jamanetworkopen.2025.31341
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PrEP Epidemiology, Modeling, and Surveillance System (PREMISE): Protocol for a PrEP Analysis Study (Preprint)2025
  2. 2Re-evaluating the Potential Impact of PrEP in Achieving HIV Elimination in the United States: Insights from Modeling2026
  3. 3Impact of HIV preexposure prophylaxis prescriptions on HIV diagnoses in New York City2024 · 1 citations
  4. 4Quantifying the number of people who would benefit from HIV pre-exposure prophylaxis (PrEP) in the United States: a comparison of behavioral, acquisition-risk based, and economic metrics2025
  5. 5Treatment as Prevention and HIV Transmission in the US2026