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September 12, 2025Open Access

Modeling metabolic disease susceptibility and resilience in genetically diverse mice

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Authors

CBCandice N. BakerJackson LaboratoryJHJeffrey M. HarderHoward Hughes Medical InstituteDSDaniel A. SkellyJackson Laboratory

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Implication

This study examines metabolic responses in diverse mice under varying diets, suggesting a complex interplay in metabolic disease susceptibility.

Key Points

  • NZO/HlLtJ mice developed overt type 2 diabetes, while CAST/EiJ showed complete resilience, highlighting genetic diversity's impact on metabolic health.
  • Analysis revealed white adipose tissue had strong strain-specific responses, indicating its crucial role in metabolism under unhealthy diets.
  • Mapping identified genetic loci related to diet responses, particularly a monocyte regulatory locus on mChr19, emphasizing genetic influences.
  • The study demonstrates the importance of considering genetic diversity when modeling metabolic diseases and responses to diets.

Cite This Study

Baker et al. (2025) studied this question.

synapsesocial.com/papers/68d44a4031b076d99fa53916https://doi.org/10.7554/elife.108435
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