Novel Preparation Method for Optimized Doxycycline‐Loaded Polycaprolactone Nanofibers

Nanomaterials can be used for targeted drug delivery, enhanced medical imaging, or cancer treatment. Electrospinning enables the creation of drug‐loaded nanofibers, facilitating sustained release and targeted delivery. A key challenge in developing drug‐loaded electrospun materials is achieving simultaneous solubilization of the polymer and the active ingredient. This study introduces a novel approach for obtaining polycaprolactone‐based nanofibers incorporating doxycycline. Doxycycline is a broad‐spectrum antibiotic, effective against a wide range of infections. Polycaprolactone is a biodegradable polyester known for its slow degradation rate, good mechanical strength, and excellent biocompatibility, making it suitable for biomedical applications. The optimal solvent mixture, enabling the simultaneous solubilization of polycaprolactone and doxycycline, is identified. The fiber diameter in drug‐loaded electrospun materials directly impacts drug release, bioavailability, and therapeutic effectiveness. Key electrospinning parameters, such as applied voltage, flow rate, and tip‐to‐collector distance, govern fiber size, influencing drug delivery efficiency. In this study, a design of experiments framework is utilized to determine the optimal electrospinning parameters. Depending on the specific application, these parameters can be adjusted to achieve the desired fiber diameter, ensuring suitability for the intended use. This study provides valuable insights into optimizing electrospinning parameters, ensuring efficient drug delivery, and advancing biomedical applications.