September 12, 2025BiomedicinesOpen Access

Association of HTR1F with Prognosis, Tumor Immune Microenvironment, and Drug Sensitivity in Cancer: A Multi-Omics Perspective

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Discussion

Multi-omics analysis demonstrates HTR1F's strong correlation with prognosis and immune modulation in cancer.

HTR1F expression is upregulated in 17 cancer types, linked to poor prognosis, especially in lung squamous cell carcinoma.
In lung squamous cell carcinoma, the area under the curve (AUC) for 1-year survival prediction was 0.912, highlighting the prognostic potential of HTR1F.
Integrative pan-cancer analysis utilized pharmacogenomic datasets covering 34 cancer types to assess drug sensitivity related to HTR1F expression.
HTR1F overexpression promotes tumor proliferation through the MAPK signaling pathway, suggesting its role as a potential therapeutic target.

Gao et al. (2025) studied this question.

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