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This is a Experimental Study study.

September 12, 2025Journal of the American Chemical Society

Stereodivergent Synthesis of Allylic All-Carbon Quaternary Centers by Bimetallic Iridium/Magnesium-Catalyzed Allylic Alkylation

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This method achieves a range of all four stereoisomers of α-allylated acetamide products effectively.
High diastereo- and enantioselectivities are observed with good yields in the allylic alkylation process.
The methodology demonstrates utility in synthesizing key intermediates, including an analgesic drug derivative.
Enhanced μ-opioid receptor activity is shown in the synthesized derivative compared to its parent compound.

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Implication

Stereodivergent allylic alkylation using iridium and magnesium catalysis produces multiple stereoisomers, suggesting new pathways in chemical synthesis.

Cite This Study

Yan et al. (2025) studied this question.

synapsesocial.com/papers/68d44b2231b076d99fa54168 https://doi.org/10.1021/jacs.5c11017

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Implication

Stereodivergent allylic alkylation using iridium and magnesium catalysis produces multiple stereoisomers, suggesting new pathways in chemical synthesis.

Stereodivergent Synthesis of Allylic All-Carbon Quaternary Centers by Bimetallic Iridium/Magnesium-Catalyzed Allylic Alkylation

Key Points

Discussion

Implication

Cite This Study

Stereodivergent Synthesis of Allylic All-Carbon Quaternary Centers by Bimetallic Iridium/Magnesium-Catalyzed Allylic Alkylation

Key Points

Discussion

Implication

Cite This Study

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