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September 12, 2025Physics of Fluids

Spiral tumor cell particle inertial focusing device based on secondary flow structure enhancement

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Authors

ZDZhengxian DanHSHuanhuan ShiJLJiacong Liao

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Overview

Novel microfluidic platform achieves high separation purity of CTCs, suggesting advancements in clinical diagnosis.

Key Points

  • The device achieved 100% separation of various cell sizes at a Reynolds number of 68, demonstrating its effectiveness.
  • Utilization of an innovative array of convex structures generated additional lift force, enhancing target cell focusing.
  • The microfluidic platform was optimized using COMSOL Multiphysics software and finite element method for detailed geometry analysis.
  • The success of the design indicates promising potential as a tool for clinical diagnosis through effective CTC isolation.

Cite This Study

Dan et al. (2025) studied this question.

synapsesocial.com/papers/68d44b2a31b076d99fa5445chttps://doi.org/10.1063/5.0288365
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