This reaction demonstrates effective aryl halide coupling in good yields using copper catalysts, indicating a new method in organic synthesis.
The coupling of N-acyl-N'-substituted hydrazines with (hetero)aryl bromides and chlorides is efficiently catalyzed by CuI/4-hydroxy picolinamide and Cu(OAc)2/6-hydroxy picolinohydrazide, respectively. Under these conditions, a broad range of (hetero)aryl halides and N-acyl-N'-substituted hydrazines react smoothly at 80-120 °C, affording the corresponding products in good to excellent yields in most cases.
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Wang et al. (2025) studied this question.
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