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This is a Quantitative Study study.

September 12, 2025Open Access

Axon termination of the SAB motor neurons in C. elegans depends on pre- and postsynaptic activity

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Findings reveal that axon termination relies on presynaptic excitability and postsynaptic muscle activity in motor neuron circuits.

Inhibition of muscle activity resulted in axonal overgrowth, indicating a vital role for postsynaptic signals.
Manipulating neuronal activity showed that increased calcium dynamics drives axonal overgrowth and reduces activity suppresses it.
C. elegans model highlights the importance of neuropeptides FLP-18 and NLP-12 in this activity-dependent process.
These results suggest how retrograde signaling and muscle-derived cues influence motor circuit formation and maintenance.

Weinreb et al. (2025) studied this question.

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September 12, 2025Open Access

View Full Paper

Ask AI

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Authors

Findings reveal that axon termination relies on presynaptic excitability and postsynaptic muscle activity in motor neuron circuits.

Inhibition of muscle activity resulted in axonal overgrowth, indicating a vital role for postsynaptic signals.
Manipulating neuronal activity showed that increased calcium dynamics drives axonal overgrowth and reduces activity suppresses it.
C. elegans model highlights the importance of neuropeptides FLP-18 and NLP-12 in this activity-dependent process.
These results suggest how retrograde signaling and muscle-derived cues influence motor circuit formation and maintenance.

Weinreb et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark