This method synthesizes α-thiocyanate ketones from aromatic ketones, suggesting a greener alternative to metal-catalyzed approaches.
A robust and environmentally benign electrochemical method for the synthesis of α‐thiocyanate ketones from aromatic ketones is reported. The protocol utilizes ammonium thiocyanate as both the thiocyanate source and supporting electrolyte in an undivided cell with platinum electrodes and an acetonitrile/water/sulfuric acid solvent system. This metal‐catalyst‐free transformation proceeds under mild conditions, exhibiting broad substrate scope, excellent functional group compatibility, and amenability to gram‐scale operations. The developed approach offers a sustainable and practical alternative for accessing these valuable thiocyanated carbonyl compounds, addressing limitations of conventional oxidative methods.
No takes yet. Share an insight, caveat, or question.
Zhang et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: