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September 12, 2025Frontiers in Bioengineering and BiotechnologyOpen Access

Injectable cinnamaldehyde–loaded ZIF-8/Gallic Acid–Grafted gelatin hydrogel for enhanced angiogenesis and skin regeneration in diabetic wound healing

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Authors

BZBo ZhouCZChen ZhangSDSheng Dai

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Overview

Injectable hydrogel promotes angiogenesis and wound healing in diabetic rats, indicating potential therapeutic benefits.

Key Points

  • The CA@ZIF-8/GGA hydrogel significantly promotes angiogenesis and skin regeneration in diabetic models.
  • In vitro results showed enhanced HUVEC proliferation and tube formation, with key markers like VEGF upregulated.
  • Using a diabetic rat model, treated wounds exhibited accelerated closure and higher granulation tissue formation.
  • The hydrogel demonstrated good systemic biocompatibility, with no observed histological abnormalities in major organs.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68d44b3831b076d99fa54cb6https://doi.org/10.3389/fbioe.2025.1660821
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Also Consider

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  1. 1Peptide‐Based Composite Hydrogels Loaded With Chlorogenic Acid for Diabetic Wound Healing2026
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  5. 5Multifunctional ZIF-91-Based GelMA Hydrogel Microneedles Patch with Antibacterial and Anti-Inflammatory Effects for Diabetic Wound Healing2026 · 3 citations