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September 12, 2025Frontiers in ImmunologyOpen Access

A splicing-based multitissue association study of joint transcriptomes identified susceptibility genes for osteoarthritis

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Authors

LZLi ZhangFZFuxin ZhaoHZHengheng Zhang

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Overview

Integrating transcriptome association studies with genetic data uncovers key genes in osteoarthritis, suggesting new therapeutic targets.

Key Points

  • Multiple genes associated with osteoarthritis were identified, particularly LTBP1, indicating its role in the disease's mechanisms.
  • Cross- and single-tissue analyses highlighted LTBP1's significant association with osteoarthritis, validated with a false discovery rate below 0.05.
  • Single-cell sequencing indicated LTBP1's dynamic role in chondrocyte differentiation and its connection to various signaling pathways.
  • Intercellular communication analysis suggested LTBP1 influences extracellular matrix formation and immune responses in osteoarthritis pathology.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68d44b3831b076d99fa54cd9https://doi.org/10.3389/fimmu.2025.1590008
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