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July 3, 2026Current Pharmaceutical Design

Cross-Tissue Transcriptome-Wide Association Study Prioritizes Candidate Genesand Compound-Associated Signatures for Osteoarthritis

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Authors

NZNing Jackie ZhangXHXinyue HuGCGuanglei Chen

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Overview

Randomized trial prioritizes candidate genes associated with osteoarthritis, suggesting new avenues for treatment.

Key Points

  • Identify candidate genes and their regulatory mechanisms linked to osteoarthritis through transcriptomic analysis.
  • Integrated Genome-Wide Association Study summary statistics with Expression Quantitative Trait Locus data.
  • Performed cross-tissue and single-tissue transcriptome-wide association analyses using UTMOST and FUSION.
  • Utilized methods like COJO, MAGMA, SMR, and GeneMANIA for prioritization and functional annotation of genes.
  • Identified 20 significant genes for knee OA and 12 for hip OA after FDR correction.
  • Prioritized TACC3 and LTBP1 for knee OA and TMEM129 for hip OA.
  • GeneMANIA indicated relevant functional networks for TACC3 and LTBP1, supporting their roles in OA.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a4755e85c29257aa257accahttps://doi.org/10.2174/0113816128481898260605051256
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A splicing-based multitissue association study of joint transcriptomes identified susceptibility genes for osteoarthritis2025
  2. 2Transcriptome analysis in osteoarthritis primary tissues identifies high-confidence effector genes2026
  3. 3Mendelian randomization based on genome-wide association studies and expression quantitative trait loci, predicting gene targets for the complexity of osteoarthritis as well as the clinical prognosis of the condition2024 · 4 citations
  4. 4Pinpointing novel targets for osteoarthritis: A comprehensive cross-omics integration analysis2025
  5. 5Multi-Omics Research Combined With Experimental Verification to Identify Potential Targets for Temporomandibular Joint Osteoarthritis2026